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It was discovered that naltrexone and bupropion combined, that could be marketed in the future as Contrave, give better weight loss results than dieting and exercise alone. Using two separate drugs to shed pounds can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you need to err along the side of caution and allow FDA do its job and demand some study be done so that the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on the medications. Researchers discovered that participants investing in this drug to get a year, dropped excess weight within 4 weeks and have kept the load off through the entire 56 weeks of the study. Contrave can be a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, that might make them far better and safer. Combo-pilling will be the newest fad or also the newest ahead under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular may be the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug could also raise hypertension and pulse rate, and really should not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. The most common unwanted side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.