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Physicians who treat opioid addiction also have the option of utilizing 'medication-assisted treatment', along with the most common medications employed in the treatment of opioid dependence today are methadone, naltrexone, and buprenorphine (Suboxone). Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done so your public recognizes the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say almost anything to keep people on their own medications. Researchers discovered that participants investing in this drug for any year, dropped a few pounds within one month and have kept the extra weight off throughout the 56 weeks in the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of many active ingredient, which might make them far better and safer. Combo-pilling could be the newest fad or better yet the newest in the future under scrutiny and thus it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that as of right now there aren't long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure and heart rate, and shouldn't be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heart rate and must not used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. Other people who should avoid using Contrave are patients being affected by bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for females who are pregnant or wanting to become pregnant.